Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.47 |
| ▸ | CHUK | O15111 | 7/20 | 0.47 |
| ▸ | IKBKG | Q9Y6K9 | 7/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896094 | 0.84 | IKBKB (0.50) | IKBKBCHUKIKBKGMEN1RECQL | |
| SCHEMBL4904668 | 0.79 | DKK1 (0.43) | CCNT1CCNA2CDK2CDK9MEN1 | |
| SCHEMBL13799539 | 0.76 | IKBKB (0.56) | IKBKBCHUKIKBKGCCNT1CCNA2 | |
| SCHEMBL2985979 | 0.75 | IKBKB (0.46) | IKBKBCHUKIKBKGCDK2MEN1 | |
| SCHEMBL2972101 | 0.74 | IKBKB (0.50) | IKBKBCHUKIKBKGMEN1RECQL | |
| Hydrochloric Acid SCHEMBL3961613 | 0.73 | IKBKB (0.51) | IKBKBCHUKIKBKGMEN1RECQL | |
| SCHEMBL4908664 | 0.73 | IKBKB (0.39) | IKBKBCHUKIKBKGCCNT1CCNA2 | |
| SCHEMBL4906521 | 0.73 | ABL1 (0.50) | CCNT1CCNA2CDK2CDK9PRKCZ | |
| SCHEMBL3969427 | 0.73 | IKBKB (0.53) | IKBKBCHUKIKBKGMEN1RECQL | |
| Hydrochloric Acid SCHEMBL3961561 | 0.72 | IKBKB (0.52) | IKBKBCHUKIKBKGMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | claimed |
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | IKBKB 1711/4885CHUK 975/4885IKBKG 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.