Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 16/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906747 | 0.97 | CTSK (0.54) | CTSKCTSLCTSSPOLBTP53 | |
| SCHEMBL4907382 | 0.93 | CTSK (0.56) | CTSKCTSLCTSSPOLBTP53 | |
| SCHEMBL4901641 | 0.85 | CTSK (0.62) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4900925 | 0.84 | CTSK (0.57) | CTSKPOLBTP53 | |
| SCHEMBL4901984 | 0.82 | CTSK (0.58) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4896899 | 0.82 | CTSK (0.53) | CTSKCTSLCTSSPOLBCTSB | |
| SCHEMBL4908109 | 0.82 | CTSK (0.51) | CTSKCTSLCTSSPOLBCTSB | |
| SCHEMBL4904863 | 0.81 | CTSK (0.54) | CTSKCTSLCTSSPOLBCTSB | |
| SCHEMBL4907511 | 0.81 | CTSK (0.50) | CTSKCTSLCTSSPOLBCTSB | |
| SCHEMBL4907381 | 0.79 | CTSK (0.51) | CTSKCTSLCTSSPOLBCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058333-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | CATALANO JOHN G | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058333-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | CTSK, CTSS, CTSE | CTSK 1/4885CTSL 12/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.