SCHEMBL4896764

SCHEMBL4896764

COC(=O)C(CCCCNC(=O)COCc1ccccc1)NC(=O)COCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 5/20 0.54
SIRT1 Q96EB6 3/20 0.54
SIRT3 Q9NTG7 1/20 0.54
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
FOLH1 Q04609 2/20 0.47
TSHR P16473 1/20 0.47
C3AR1 Q16581 1/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4905245 0.93 SIRT2 (0.51) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11925819 0.91 SIRT2 (0.53) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11907039 0.91 SIRT2 (0.53) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11925972 0.89 SIRT2 (0.52) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11907490 0.89 SIRT2 (0.52) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL7226973 0.87 ANPEP (0.52) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL16846627 0.84 SIRT2 (0.49) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11907491 0.82 SIRT2 (0.49) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11925821 0.81 GLP1R (0.47) SIRT2SIRT1SIRT3CA1CA2
SCHEMBL11909269 0.81 GLP1R (0.47) SIRT2SIRT1SIRT3CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8754135-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2014-06-17 US disclosed
US-8754135-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2014-06-17 US disclosed
US-8754135-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2014-06-17 US disclosed
US-20130317120-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-11-28 US disclosed
US-8519156-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2013-08-27 US disclosed
US-8519156-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2013-08-27 US disclosed
US-8519156-B2 Functionalized non-phenolic amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2013-08-27 US disclosed
US-20130116446-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-05-09 US disclosed
US-20130116446-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-05-09 US disclosed
US-20130116446-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-05-09 US disclosed
US-8367108-B2 Hydrolyzable polyesters, polyurethanes, polyamideester copolymers, polyamides, and polyanhydrides; biodegradable, bioresorbable polymers for tissue engineering, implantable medical devices, and time-release drug delivery systems BEZWADA BIOMEDICAL, LLC (US) 2013-02-05 US disclosed
US-8367108-B2 Hydrolyzable polyesters, polyurethanes, polyamideester copolymers, polyamides, and polyanhydrides; biodegradable, bioresorbable polymers for tissue engineering, implantable medical devices, and time-release drug delivery systems BEZWADA BIOMEDICAL, LLC (US) 2013-02-05 US disclosed
US-8367108-B2 Hydrolyzable polyesters, polyurethanes, polyamideester copolymers, polyamides, and polyanhydrides; biodegradable, bioresorbable polymers for tissue engineering, implantable medical devices, and time-release drug delivery systems BEZWADA BIOMEDICAL, LLC (US) 2013-02-05 US disclosed
US-20080057127-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2008-03-06 US disclosed
US-20080057127-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2008-03-06 US disclosed
US-20080057127-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2008-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130317120-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM SLC1A5, SLC7A1, BCAT2 SIRT2 3319/4885SIRT1 3096/4885SIRT3 3518/4885
US-20080057127-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM SLC1A5, SLC7A1, BCAT2 SIRT2 3319/4885SIRT1 3096/4885SIRT3 3518/4885
US-20130116446-A1 FUNCTIONALIZED NON-PHENOLIC AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM SLC1A5, SLC7A1, BCAT2 SIRT2 3319/4885SIRT1 3096/4885SIRT3 3518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.