Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.51 |
| ▸ | EPOR | P19235 | 2/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896764 | 0.87 | SIRT2 (0.54) | CA1CA2SIRT2SIRT1SIRT3 | |
| SCHEMBL1840309 | 0.84 | SIRT2 (0.61) | ANPEPCA1CA2CPB1CPB2 | |
| SCHEMBL6477219 | 0.84 | SIRT2 (0.61) | ANPEPCA1CA2CPB1CPB2 | |
| SCHEMBL1840311 | 0.84 | SIRT2 (0.61) | ANPEPCA1CA2CPB1CPB2 | |
| Hydrochloric Acid SCHEMBL3952162 | 0.83 | SIRT2 (0.60) | ANPEPCA1CA2CPB1CPB2 | |
| Hydrochloric Acid SCHEMBL3952159 | 0.83 | SIRT2 (0.60) | ANPEPCA1CA2CPB1CPB2 | |
| Hydrochloric Acid SCHEMBL6528872 | 0.83 | SIRT2 (0.60) | ANPEPCA1CA2CPB1CPB2 | |
| SCHEMBL28859034 | 0.82 | LNPEP (0.56) | ANPEPLNPEPERAP2ERAP1 | |
| Charcoal, Activated SCHEMBL29433728 | 0.81 | ANPEP (0.55) | ANPEPLNPEPEPORERAP2ERAP1 | |
| SCHEMBL4905245 | 0.81 | SIRT2 (0.51) | CA1CA2SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5981511-A | AN ENZYME INHIBITOR FOR REDUCING NITRIC OXIDE, TREATING HYPOTENSION SUCH AS TOXIC SHOCK AND THERAPY WITH CERTAIN CYTOKINES | G.D. SEARLE & CO. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |