Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 13/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585245 | 0.86 | MAPK11 (0.40) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL8554729 | 0.67 | MAPK13 (0.43) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4920703 | 0.66 | MAPK14 (0.51) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5566132 | 0.65 | MAPK14 (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL13149934 | 0.62 | KMT2A (0.46) | — | |
| SCHEMBL4585911 | 0.61 | MAPK14 (0.51) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL6664250 | 0.61 | MAPK14 (0.57) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL27907139 | 0.61 | FAAH (0.62) | — | |
| SCHEMBL7677062 | 0.61 | MAPK14 (0.36) | MAPK13MAPK12MAPK11MAPK14BRAF | |
| SCHEMBL4587310 | 0.61 | MAPK14 (0.61) | MAPK13MAPK12MAPK11MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545535-A4 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1545535-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004021988-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2004-03-18 | — | — | WO | disclosed |