Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 6/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897620 | 0.86 | MAPK13 (0.38) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL8554729 | 0.79 | MAPK13 (0.43) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL4920703 | 0.79 | MAPK14 (0.51) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4603572 | 0.69 | BRAF (0.42) | BRAF | |
| SCHEMBL5566132 | 0.68 | MAPK14 (0.49) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4585911 | 0.65 | MAPK14 (0.51) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL5815240 | 0.65 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL27907139 | 0.65 | FAAH (0.62) | — | |
| SCHEMBL5817719 | 0.64 | NOS3 (0.41) | MAPK14 | |
| SCHEMBL8549534 | 0.63 | MAPK14 (0.50) | MAPK11MAPK14MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539121-A4 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1583535-A4 | METHODS FOR TREATING DIABETES | SCIOS INC (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1583535-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1539121-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004053107-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2004019873-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2004-03-11 | — | — | WO | disclosed |