Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549534 | 0.85 | MAPK14 (0.50) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL5819403 | 0.82 | EGFR (0.43) | — | |
| SCHEMBL4584849 | 0.81 | CSNK1A1 (0.60) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL4025352 | 0.81 | CSNK1A1 (0.60) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL8551836 | 0.80 | CSNK1A1 (0.46) | MAPK13MAPK12MAPK11MAPK14HPGDS | |
| SCHEMBL6578498 | 0.80 | MAPK14 (0.61) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL5817684 | 0.79 | GPR119 (0.40) | MAPK14GRIA1GPR119MMP13 | |
| SCHEMBL4585245 | 0.79 | MAPK11 (0.40) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5817608 | 0.78 | CDK2 (0.43) | GRIA1CSNK1A1CSNK1DMMP13HTT | |
| SCHEMBL26914072 | 0.77 | GPR119 (0.47) | POLBGPR119HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831830-A4 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0831830-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040143-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |