⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21687926 | 0.78 | PPM1B (0.39) | — | |
| SCHEMBL27287166 | 0.78 | USP2 (0.34) | — | |
| SCHEMBL28171170 | 0.74 | — | — | |
| SCHEMBL5789732 | 0.72 | — | — | |
| SCHEMBL9540306 | 0.72 | — | — | |
| SCHEMBL2480472 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL5790890 | 0.70 | — | — | |
| SCHEMBL27582521 | 0.70 | — | — | |
| SCHEMBL11484300 | 0.68 | — | — | |
| SCHEMBL2708044 | 0.67 | KMT2A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110467608-A | A kind of synthetic method of emtricitabine | WUHAN INST TECHNOLOGY | 2019-11-19 | — | — | CN | claimed |
| CN-110437216-A | A kind of synthetic method of Lamivudine | WUHAN INST TECHNOLOGY | 2019-11-12 | — | — | CN | claimed |
| CN-110467608-A | A kind of synthetic method of emtricitabine | WUHAN INST TECHNOLOGY | 2019-11-19 | — | — | CN | disclosed |
| CN-110437216-A | A kind of synthetic method of Lamivudine | WUHAN INST TECHNOLOGY | 2019-11-12 | — | — | CN | disclosed |
| US-20080275023-A1 | N-Hydroxyamides Omege-Substituted with Tricyclic Groups as Histone Deacetylase Inhibitors, Their Preparation and Use in Pharmaceutical Formulations | MENARIN INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2008-11-06 | — | — | US | disclosed |
| EP-1863776-A1 | N-HYDROXYAMIDES OMEGA-SUBSTITUTED WITH TRICYCLIC GROUPS AS HISTONE DEACETYLASE INHIBITORS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS | Menarini International Operations Luxembourg S.A. (LU) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006097449-A1 | N-HYDROXYAMIDES OMEGA-SUBSTITUTED WITH TRICYCLIC GROUPS AS HISTONE DEACETYLASE INHIBITORS, THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2006-09-21 | — | — | WO | disclosed |