Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | PRKX | P51817 | 3/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897776 | 1.00 | ATM (0.54) | ATMCYP17A1ROCK2ROCK1PRKACA | |
| SCHEMBL740216 | 0.86 | ATM (0.55) | ATMCYP17A1CYP3A4APPCTSS | |
| SCHEMBL740215 | 0.86 | ATM (0.55) | ATMCYP17A1CYP3A4APPCTSS | |
| SCHEMBL271855 | 0.86 | ATM (0.71) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL257912 | 0.86 | ATM (0.71) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL1529562 | 0.86 | ATM (0.71) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL6479279 | 0.84 | CTSS (0.57) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL6479222 | 0.84 | CTSS (0.57) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL21676555 | 0.84 | ATM (0.55) | ATMMAPK1CYP3A4APPCTSS | |
| SCHEMBL6479218 | 0.84 | CTSS (0.57) | ATMMAPK1CYP3A4APPCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
| CN-1202096-C | 2-aminothiazoline derivatives and their use as no-synthase inhibitors | AVENTIS PHARMA SA (FR) | 2005-05-18 | — | — | CN | disclosed |
| CN-1444572-A | 2-aminothiazoline derivatives and their use as no-synthase inhibitors | AVENTIS PHARMA SA (FR) | 2003-09-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | ATM 45/4885CYP17A1 1806/4885ROCK2 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.