Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.42 |
| ▸ | CCND1 | P24385 | 7/20 | 0.42 |
| ▸ | CCND3 | P30281 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902946 | 0.91 | CTSC (0.48) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4893138 | 0.90 | PKMYT1 (0.43) | CDK4CDK6CCND1CCND3CDK2 | |
| Hydrochloric Acid SCHEMBL5317119 | 0.87 | CDK2 (0.44) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4894058 | 0.82 | CTSC (0.40) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4891073 | 0.81 | CTSC (0.40) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4898906 | 0.80 | CDK2 (0.43) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4893335 | 0.79 | CTSC (0.50) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4892385 | 0.79 | CDK2 (0.42) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL4902787 | 0.78 | EDNRA (0.38) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL4898735 | 0.77 | KARS1 (0.49) | CDK4CDK6CCND1CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | CDK4 2754/4885CDK6 2720/4885CCND1 4529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.