Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 10/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.42 |
| ▸ | CCND3 | P30281 | 4/20 | 0.42 |
| ▸ | CCND1 | P24385 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256909 | 0.90 | KARS1 (0.47) | KARS1TYK2CDK4CDK6CCND3 | |
| Hydrochloric Acid SCHEMBL4896818 | 0.89 | WEE1 (0.47) | KARS1CDK4CDK6CCND3CCND1 | |
| SCHEMBL4902825 | 0.82 | HPGDS (0.42) | KARS1TYK2WEE1 | |
| SCHEMBL3138726 | 0.81 | CCNA2 (0.43) | TYK2CDK4CDK6CCND3CCND1 | |
| Hydrochloric Acid SCHEMBL3147026 | 0.80 | CCNA2 (0.42) | TYK2CDK4CDK6CCND3CCND1 | |
| SCHEMBL3128560 | 0.80 | CCNA2 (0.44) | TYK2CDK4CDK6CCND3CCND1 | |
| SCHEMBL4900079 | 0.79 | CYP1A1 (0.43) | KARS1TYK2CDK4CDK6CCND3 | |
| Hydrochloric Acid SCHEMBL3143181 | 0.79 | CCNA2 (0.44) | TYK2CDK4CDK6CCND3CCND1 | |
| SCHEMBL4900205 | 0.77 | NPC1 (0.40) | KARS1CDK9 | |
| SCHEMBL4899495 | 0.77 | CDK4 (0.42) | TYK2CDK4CDK6CCND3CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | KARS1 512/4885TYK2 2831/4885CDK4 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.