Sugi Predict

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SCHEMBL4899741

SCHEMBL4899741

Cc1ccc(S(=O)(=O)NCCOc2cc(Cl)cc(Cl)c2)cc1C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.56
▸ TDP1 Q9NUW8 1/20 0.50
▸ POLB P06746 2/20 0.49
▸ HTT P42858 3/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.46
▸ PTGDR2 Q9Y5Y4 1/20 0.46
▸ MAPK1 P28482 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ ACLY P53396 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ RECQL P46063 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4903029 0.91 TDP1 (0.50) LMNATDP1HTTMEN1KMT2A
SCHEMBL4899834 0.83 LMNA (0.60) LMNATDP1POLBHTTMEN1
SCHEMBL4906098 0.82 LMNA (0.54) LMNATDP1POLBHTTMEN1
SCHEMBL4895501 0.81 LMNA (0.58) LMNATDP1POLBHTTMEN1
SCHEMBL4903039 0.78 LMNA (0.52) LMNATDP1POLBHTTMEN1
SCHEMBL4901112 0.78 LMNA (0.54) LMNATDP1HTTMEN1KMT2A
SCHEMBL4906801 0.77 AKR1C3 (0.56) LMNAPOLBMEN1KMT2ANPSR1
SCHEMBL4906509 0.77 ALDH1A1 (0.57) LMNAPOLBHTTMEN1KMT2A
SCHEMBL4907013 0.77 AKR1C3 (0.53) LMNAMEN1KMT2ANPSR1ALDH1A1
SCHEMBL4906713 0.76 TDP1 (0.59) LMNATDP1POLBHTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885TDP1 3363/4885POLB 1488/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885TDP1 3653/4885POLB 1807/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885TDP1 3653/4885POLB 1807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.