Sugi Predict

Sugi Predict / Compounds / SCHEMBL4900699

SCHEMBL4900699

SCHEMBL4900699

COC(=O)c1cc(S(=O)(=O)NCCc2ccc(Oc3cccnc3)cc2)cc(C)c1C

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TBXAS1 P24557 7/20 0.53
▸ TBXA2R P21731 3/20 0.44
▸ KMT2A Q03164 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ PKM P14618 2/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ AKR1C3 P42330 1/20 0.43
▸ ADRB2 P07550 2/20 0.42
▸ ADRB1 P08588 2/20 0.42
▸ ADRB3 P13945 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4906367 0.92 TBXAS1 (0.56) TBXAS1TBXA2RPKMMAPK1HTT
SCHEMBL4903600 0.91 TBXAS1 (0.55) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4906174 0.90 HTT (0.52) KMT2AMEN1GAAPKMMAPK1
SCHEMBL4903947 0.90 MEN1 (0.51) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4908270 0.85 TBXAS1 (0.53) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4906445 0.85 PKM (0.47) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4898037 0.85 ALDH1A1 (0.56) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4904277 0.85 MAPT (0.50) TBXA2RKMT2AMEN1AKR1C3ALDH1A1
SCHEMBL4904169 0.84 ALDH1A1 (0.46) TBXAS1TBXA2RKMT2AMEN1GAA
SCHEMBL4903960 0.83 TBXAS1 (0.57) TBXAS1TBXA2RKMT2APKMMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD TBXAS1 271/4885TBXA2R 338/4885KMT2A 3602/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD TBXAS1 271/4885TBXA2R 330/4885KMT2A 3530/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD TBXAS1 271/4885TBXA2R 330/4885KMT2A 3530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.