Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401118 | 0.90 | DDX3X (0.42) | DDX3XCCR3ALDH1A1EPHX2HRH3 | |
| SCHEMBL401741 | 0.86 | ALDH1A1 (0.43) | DDX3XSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL399571 | 0.85 | EPHX2 (0.47) | HTTMEN1KMT2ACCR3NPC1 | |
| SCHEMBL3188110 | 0.83 | RORC (0.43) | DDX3XHTTSMN1; SMN2MEN1PABPC1 | |
| SCHEMBL402606 | 0.83 | EPHX2 (0.46) | DDX3XSMN1; SMN2MEN1KMT2AEPHX2 | |
| SCHEMBL460041 | 0.82 | DDX3X (0.43) | DDX3XCCR3EPHX2 | |
| SCHEMBL400356 | 0.82 | RORC (0.44) | HTTSMN1; SMN2MEN1PABPC1KMT2A | |
| SCHEMBL3201705 | 0.82 | RORC (0.42) | DDX3XHTTSMN1; SMN2MEN1PABPC1 | |
| SCHEMBL3199702 | 0.82 | DDX3X (0.43) | DDX3XSMN1; SMN2CCR3NPC1RAB9A | |
| SCHEMBL3212233 | 0.82 | NPC1 (0.45) | HTTSMN1; SMN2MEN1PABPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959738-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070626-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |