Sugi Predict

Sugi Predict / Compounds / SCHEMBL4900980

SCHEMBL4900980

SCHEMBL4900980

CCc1ccc(S(=O)(=O)NCCc2ccc(Oc3ccc(C)c(C)c3)cc2)cc1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 2/20 0.49
▸ PKM P14618 1/20 0.49
▸ HTT P42858 1/20 0.49
▸ AKR1C3 P42330 4/20 0.48
▸ ALDH1A1 P00352 5/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ LMNA P02545 2/20 0.45
▸ TP53 P04637 1/20 0.44
▸ POLB P06746 2/20 0.43
▸ MAPT P10636 1/20 0.43
▸ RECQL P46063 1/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ TBXA2R P21731 1/20 0.43
▸ TBXAS1 P24557 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ SFRP1 Q8N474 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4907512 0.92 LMNA (0.54) MAPK1PKMHTTAKR1C3ALDH1A1
SCHEMBL4895103 0.91 TP53 (0.49) AKR1C3ALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4903953 0.91 PKM (0.48) MAPK1PKMHTTAKR1C3ALDH1A1
SCHEMBL4906430 0.90 AKR1C3 (0.56) MAPK1AKR1C3ALDH1A1SMN1; SMN2POLB
SCHEMBL4895722 0.88 AKR1C3 (0.55) AKR1C3ALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4898067 0.88 ALDH1A1 (0.57) AKR1C3ALDH1A1SMN1; SMN2LMNATP53
SCHEMBL4904654 0.87 ALDH1A1 (0.52) MAPK1PKMHTTAKR1C3ALDH1A1
SCHEMBL4899868 0.86 AKR1C3 (0.48) MAPK1AKR1C3ALDH1A1SMN1; SMN2POLB
SCHEMBL4900618 0.86 PKM (0.48) MAPK1PKMHTTAKR1C3ALDH1A1
SCHEMBL4902663 0.85 PKM (0.53) MAPK1PKMHTTAKR1C3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD MAPK1 3332/4885PKM 896/4885HTT 711/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD MAPK1 3366/4885PKM 861/4885HTT 696/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD MAPK1 3366/4885PKM 861/4885HTT 696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.