Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.61 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | BCR | P11274 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 3/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12276138 | 0.93 | SYK (0.61) | PIK3CGCAMKK2MAPK8GSK3BABL1 | |
| SCHEMBL4903233 | 0.88 | JAK2 (0.65) | PIK3CGMAPK8GSK3BABL1BCR | |
| SCHEMBL27115956 | 0.87 | ABL1 (0.60) | PIK3CGCAMKK2MAPK8GSK3BABL1 | |
| SCHEMBL2939791 | 0.86 | PIK3CG (0.68) | PIK3CGCAMKK2MAPK8GSK3BABL1 | |
| SCHEMBL4901211 | 0.84 | CDK5 (0.75) | PIK3CGGSK3BABL1BCRSRC | |
| SCHEMBL14254081 | 0.84 | CAMKK2 (0.55) | PIK3CGCAMKK2MAPK8GSK3BABL1 | |
| SCHEMBL12521769 | 0.84 | PRKCA (0.59) | PIK3CGCAMKK2GSK3BABL1BCR | |
| SCHEMBL4895700 | 0.83 | ABL1 (0.75) | ABL1BCRSRCJAK2PRKCA | |
| SCHEMBL3045102 | 0.83 | JAK2 (0.49) | PIK3CGCAMKK2MAPK8GSK3BABL1 | |
| SCHEMBL3747896 | 0.83 | CAMKK2 (0.80) | PIK3CGCAMKK2MAPK8GSK3BABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | PIK3CG 1709/4885CAMKK2 4550/4885MAPK8 3140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.