Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923061 | 0.75 | KDR (0.41) | QPCTPOLBKDR | |
| SCHEMBL2544215 | 0.74 | CDK2 (0.46) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL5760871 | 0.73 | QPCT (0.51) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL31036089 | 0.72 | EGFR (0.43) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL21646358 | 0.72 | ADRA2A (0.42) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL6625328 | 0.72 | MAPT (0.47) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4598414 | 0.72 | POLB (0.52) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4910893 | 0.72 | ROCK1 (0.47) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL7185293 | 0.72 | MAPT (0.53) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL18789600 | 0.71 | ADRA2A (0.40) | ADRA2AADRA2CADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | ADRA2A 4099/4885ADRA2C 4435/4885ADRA1D 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.