Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546216 | 0.81 | MAPK1 (0.60) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL1265834 | 0.78 | PARP1 (0.60) | MAPTALDH1A1KDM4ECDK1PARP1 | |
| SCHEMBL31411494 | 0.78 | PARP1 (0.60) | MAPTALDH1A1KDM4ECDK1PARP1 | |
| SCHEMBL2542670 | 0.78 | KDM4E (0.53) | MAPTALDH1A1GAAKDM4ECDK1 | |
| Iodide SCHEMBL31411461 | 0.76 | PARP1 (0.58) | MAPTALDH1A1KDM4ECDK1PARP1 | |
| SCHEMBL11390047 | 0.76 | ALDH1A1 (0.81) | MAPTALDH1A1GAAKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL10529934 | 0.72 | ALDH1A1 (0.73) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL4903216 | 0.72 | ADRA2A (0.42) | MAPTALDH1A1KDM4ECDK1RAB9A | |
| SCHEMBL11397234 | 0.71 | MAPT (0.71) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL12600384 | 0.68 | MEN1 (0.55) | MAPTALDH1A1GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |