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SCHEMBL4904145

SCHEMBL4904145

COC(=O)c1cc(S(=O)(=O)N(CCc2ccc(OCc3cc(F)cc(F)c3)cc2)Cc2cc(F)cc(F)c2)ccc1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 1/20 0.45
▸ MMP9 P14780 1/20 0.45
▸ MMP14 P50281 1/20 0.45
▸ ADAM17 P78536 1/20 0.45
▸ TAS2R14 Q9NYV8 2/20 0.43
▸ BMP1 P13497 4/20 0.41
▸ MAPT P10636 4/20 0.41
▸ LMNA P02545 2/20 0.41
▸ TP53 P04637 5/20 0.41
▸ CA12 O43570 1/20 0.40
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40
▸ CA4 P22748 1/20 0.40
▸ CA9 Q16790 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ TSHR P16473 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ FFAR4 Q5NUL3 1/20 0.39
▸ POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4900038 0.92 TAS2R14 (0.46) MMP2MMP9MMP14ADAM17TAS2R14
SCHEMBL4905637 0.91 TAS2R14 (0.44) MMP9ADAM17TAS2R14BMP1MAPT
SCHEMBL4906541 0.91 TAS2R14 (0.46) MMP2MMP9MMP14ADAM17TAS2R14
SCHEMBL4904285 0.89 TP53 (0.45) TAS2R14BMP1MAPTLMNATP53
SCHEMBL4908413 0.88 CNR2 (0.48) MMP9ADAM17TAS2R14BMP1MAPT
SCHEMBL4895626 0.87 TAS2R14 (0.56) MMP2MMP9MMP14ADAM17TAS2R14
SCHEMBL4902732 0.86 KMT2A (0.48) MMP2MMP9MMP14ADAM17TAS2R14
SCHEMBL4905982 0.86 BMP1 (0.49) MMP2MMP9TAS2R14BMP1MAPT
Methane SCHEMBL6506917 0.85 BMP1 (0.48) MMP2MMP9ADAM17TAS2R14BMP1
SCHEMBL4908668 0.83 TAS2R14 (0.49) MMP9ADAM17TAS2R14CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD MMP2 4348/4885MMP9 4666/4885MMP14 4675/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD MMP2 4105/4885MMP9 4632/4885MMP14 4597/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD MMP2 4105/4885MMP9 4632/4885MMP14 4597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.