Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VPS4B | O75351 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.50 |
| ▸ | DRD2 | P14416 | 12/20 | 0.50 |
| ▸ | HTR2B | P41595 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900652 | 0.83 | VPS4B (0.58) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL5384502 | 0.83 | VPS4B (0.58) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL4905309 | 0.83 | VPS4B (0.61) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL4900711 | 0.83 | VPS4B (0.58) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL4904352 | 0.81 | VPS4B (0.56) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL833780 | 0.76 | HTR1B (0.65) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL833788 | 0.76 | HTR1B (0.65) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL833781 | 0.76 | HTR1B (0.65) | VPS4BVCPSLC6A4DRD2HTR2B | |
| SCHEMBL13478770 | 0.76 | KMT2A (0.64) | VPS4BVCPHTR2AHTR1AACHE | |
| SCHEMBL25498044 | 0.75 | VPS4B (0.49) | VPS4BVCPSLC6A4DRD2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | disclosed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | TPH1, TPH2, HTR2C | VPS4B 4111/4885VCP 4032/4885SLC6A4 25/4885 |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | VPS4B 4111/4885VCP 4032/4885SLC6A4 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.