Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655594 | 0.90 | ABCC4 (0.41) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL22367729 | 0.86 | ACLY (0.43) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL10652723 | 0.86 | TSHR (0.41) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL20140467 | 0.86 | ACLY (0.43) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL17950998 | 0.86 | MAPT (0.67) | MAPTABCC4CYP2D6CYP2C19ACLY | |
| SCHEMBL6067673 | 0.82 | MAPT (0.45) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL2894770 | 0.82 | ACLY (0.61) | MAPTABCC4TSHRACLYALDH1A1 | |
| SCHEMBL10207253 | 0.78 | TSHR (0.38) | MAPTABCC4TSHRCYP2D6CYP2C19 | |
| SCHEMBL1975627 | 0.78 | ARG1 (0.53) | MAPTABCC4TSHRCYP2C19ACLY | |
| SCHEMBL1977004 | 0.78 | ARG1 (0.53) | MAPTABCC4TSHRCYP2C19ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834482-B2 | Agents modulating beta-catenin functions and methods thereof | FOG PHARMACEUTICALS, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20230357320-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | PARABILIS MEDICINES, INC. | 2023-11-09 | — | — | US | disclosed |
| US-9556227-B2 | Stitched polypeptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-01-31 | — | — | US | disclosed |
| EP-1446437-B1 | COMPOUNDS CONTAINING QUATERNARY CARBONS, MEDICAL DEVICES, AND METHODS | MEDTRONIC INC (US) | 2015-04-15 | — | — | EP | disclosed |
| US-20140011979-A1 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-01-09 | — | — | US | disclosed |
| US-20100184645-A1 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-22 | — | — | US | disclosed |
| US-20080064845-A9 | Compounds containing quaternary carbons, medical devices, and methods | MEDTRONIC, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20060252905-A1 | Compounds containing quaternary carbons, medical devices, and methods | MEDTRONIC, INC. (US) | 2006-11-09 | — | — | US | disclosed |
| US-7101956-B2 | Compounds containing quaternary carbons, medical devices, and methods | MEDTRONIC, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1446437-A1 | COMPOUNDS CONTAINING QUATERNARY CARBONS, MEDICAL DEVICES, AND METHODS | Medtronic, Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030125499-A1 | Compounds containing quaternary carbons, medical devices, and methods | MEDTRONIC, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2003042273-A1 | COMPOUNDS CONTAINING QUATERNARY CARBONS, MEDICAL DEVICES, AND METHODS | MEDTRONIC, INC. (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357320-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | ESRRB, ESR1, ESRRA | MAPT 2983/4885ABCC4 4741/4885TSHR 671/4885 |
| US-20100184645-A1 | STITCHED POLYPEPTIDES | VIP, IAPP, NGLY1 | MAPT 2152/4885ABCC4 3682/4885TSHR 2524/4885 |
| US-20140011979-A1 | STITCHED POLYPEPTIDES | VIP, IAPP, NGLY1 | MAPT 2152/4885ABCC4 3682/4885TSHR 2524/4885 |
| US-11834482-B2 | Agents modulating beta-catenin functions and methods thereof | CTNNB1, CTNNBL1, CTNNA1 | MAPT 3674/4885ABCC4 4161/4885TSHR 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.