Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 known ✓ | P52333 | 5/20 | 0.63 |
| ▸ | JAK2 known ✓ | O60674 | 5/20 | 0.63 |
| ▸ | BTK known ✓ | Q06187 | 1/20 | 0.63 |
| ▸ | JAK1 known ✓ | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 known ✓ | P29597 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 13/20 | 0.63 |
| ▸ | AURKA | O14965 | 6/20 | 0.63 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.63 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.63 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.63 |
| ▸ | IGF1R | P08069 | 2/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | LTK | P29376 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434985 | 0.93 | NTRK1 (0.73) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL588730 | 0.93 | NTRK1 (0.73) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL18281508 | 0.93 | NTRK1 (0.73) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL31060183 | 0.93 | NTRK1 (0.73) | NTRK1AURKAJAK3JAK2NTRK3 | |
| Phosphoric Acid SCHEMBL3041888 | 0.91 | NTRK1 (0.66) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL3034183 | 0.85 | NTRK1 (0.71) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL3041951 | 0.84 | NTRK1 (0.69) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL17433341 | 0.84 | NTRK1 (0.59) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL588783 | 0.82 | JAK3 (0.57) | NTRK1AURKAJAK3JAK2NTRK3 | |
| SCHEMBL3036561 | 0.82 | JAK2 (0.58) | NTRK1AURKAJAK3JAK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ABL1, FLT3, ERBB2 | JAK3 73/4885JAK2 32/4885BTK 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.