Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 12/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 12/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4904503 | 0.93 | KEAP1 (0.52) | KEAP1NFE2L2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4906333 | 0.87 | NPC1 (0.48) | KEAP1NFE2L2HPGDALDH1A1CTSV | |
| SCHEMBL4905993 | 0.85 | LMNA (0.56) | KEAP1NFE2L2LMNAHPGDALDH1A1 | |
| SCHEMBL4905129 | 0.79 | MMP13 (0.52) | KEAP1NFE2L2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4895352 | 0.79 | KMT2A (0.54) | KEAP1NFE2L2LMNAHPGDALDH1A1 | |
| SCHEMBL9049982 | 0.78 | LMNA (0.70) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4898232 | 0.78 | LMNA (0.54) | KEAP1NFE2L2LMNAHPGDALDH1A1 | |
| SCHEMBL4903799 | 0.78 | LMNA (0.59) | KEAP1NFE2L2LMNAHPGDALDH1A1 | |
| SCHEMBL4907030 | 0.77 | LMNA (0.51) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4897482 | 0.77 | LMNA (0.53) | KEAP1NFE2L2LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | KEAP1 810/4885NFE2L2 446/4885LMNA 319/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | KEAP1 810/4885NFE2L2 446/4885LMNA 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.