Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 9/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | UTRN | P46939 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 3/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895950 | 0.93 | LMNA (0.48) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4905178 | 0.91 | PTPN1 (0.47) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4897744 | 0.91 | PTPN1 (0.49) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4912012 | 0.86 | PTPN1 (0.46) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4904660 | 0.84 | LMNA (0.49) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4903801 | 0.84 | LMNA (0.49) | PTPN1PTPN5PTPN2HDAC6CYP1A2 | |
| SCHEMBL4905062 | 0.82 | ALDH1A1 (0.42) | PKMLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4904190 | 0.81 | NPC1 (0.46) | HDAC6PKMLMNANPC1RAB9A | |
| SCHEMBL4895610 | 0.80 | ALDH1A1 (0.41) | PKMLMNANPC1RAB9AMEN1 | |
| SCHEMBL4909040 | 0.80 | LMNA (0.44) | PTPN1PTPN5PTPN2HDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | PTPN1 1702/4885PTPN5 1700/4885PTPN2 2168/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | PTPN1 2340/4885PTPN5 2304/4885PTPN2 2720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.