Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 6/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4912012 | 0.92 | PTPN1 (0.46) | HPGDALDH1A1HSD17B10KDM4ENPC1 | |
| SCHEMBL4903801 | 0.90 | LMNA (0.49) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4904660 | 0.86 | LMNA (0.49) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4895950 | 0.84 | LMNA (0.48) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4905178 | 0.84 | PTPN1 (0.47) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4904123 | 0.82 | LMNA (0.43) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4906978 | 0.81 | NFKB1 (0.46) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4897744 | 0.80 | PTPN1 (0.49) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4906129 | 0.80 | PTPN1 (0.46) | LMNAHPGDALDH1A1ALOX15HSD17B10 | |
| SCHEMBL4903620 | 0.79 | C1R (0.42) | LMNAHPGDALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LMNA 319/4885HPGD 724/4885ALDH1A1 2956/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LMNA 319/4885HPGD 724/4885ALDH1A1 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.