Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | DKK1 | O94907 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906712 | 0.85 | DKK1 (0.37) | HDAC8DKK1GSK3BMAPK8CAMKK2 | |
| SCHEMBL4903644 | 0.81 | DKK1 (0.40) | HDAC8DKK1GSK3BCDK2MAPK8 | |
| SCHEMBL4898423 | 0.78 | CDK2 (0.35) | HDAC8DKK1GSK3BCDK2CDC7 | |
| SCHEMBL4904065 | 0.77 | DKK1 (0.31) | DKK1GSK3B | |
| SCHEMBL4911695 | 0.74 | NPC1 (0.38) | GSK3BMAP4K4MAPK8CAMKK2 | |
| SCHEMBL4897636 | 0.73 | HDAC8 (0.41) | HDAC8DKK1GSK3BMAPK10MAPK8 | |
| SCHEMBL4904668 | 0.69 | DKK1 (0.43) | HDAC8DKK1GSK3BCDK2MKNK2 | |
| SCHEMBL4908664 | 0.68 | IKBKB (0.39) | CDK2CDC7CCNA2 | |
| SCHEMBL4896096 | 0.67 | IKBKB (0.37) | — | |
| SCHEMBL3648299 | 0.67 | MAPK10 (0.60) | HDAC8GSK3BCDK2CDC7CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | HDAC8 3791/4885DKK1 9/4885GSK3B 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.