Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 15/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370362 | 0.91 | LMNA (0.58) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL4903824 | 0.86 | LMNA (0.53) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL12151145 | 0.85 | POLB (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL27720173 | 0.84 | LMNA (0.56) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL6343767 | 0.82 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL27912402 | 0.82 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL4905756 | 0.82 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL3372534 | 0.80 | LMNA (0.54) | LMNAMAPTKDM4ESMN1; SMN2POLB | |
| SCHEMBL2236881 | 0.79 | GFER (0.66) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL7895624 | 0.79 | LMNA (0.51) | LMNAMAPTKDM4ESMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | LMNA 317/4885MAPT 1858/4885KDM4E 3750/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LMNA 319/4885MAPT 1786/4885KDM4E 3834/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LMNA 319/4885MAPT 1786/4885KDM4E 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.