SCHEMBL7895624

SCHEMBL7895624

NCc1csc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.51
MAPT P10636 3/20 0.51
HTT P42858 1/20 0.51
KDM4E B2RXH2 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TP53 P04637 9/20 0.50
POLB P06746 1/20 0.49
LTA4H P09960 1/20 0.49
RHOC P08134 1/20 0.46
RHOA P61586 1/20 0.46
PIM1 P11309 2/20 0.46
DPP4 P27487 1/20 0.45
DPP8 Q6V1X1 1/20 0.45
DPP9 Q86TI2 1/20 0.45
GFER P55789 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16210506 0.98 LMNA (0.50) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL4905756 0.88 LMNA (0.55) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL4903824 0.85 LMNA (0.53) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL2056125 0.84 TP53 (0.55) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL2236881 0.84 GFER (0.66) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL4553327 0.84 LMNA (0.51) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL2088799 0.84 LMNA (0.54) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL12151145 0.84 POLB (0.55) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL12151210 0.84 LMNA (0.51) LMNAMAPTHTTKDM4ESMN1; SMN2
SCHEMBL1715677 0.83 IDO1 (0.51) LMNAMAPTHTTKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12313546-B2 Sensing devices and chemosensors and compositions relating thereto ROBERT BOSCH GMBH (DE) 2025-05-27 US disclosed
US-20220034808-A1 SENSING DEVICES AND CHEMOSENSORS AND COMPOSITIONS RELATING THERETO ROBERT BOSCH GMBH (DE) 2022-02-03 US disclosed
CN-113004267-A Acceptor and spacer for fluorescence-based lead ion chemical sensors 罗伯特·博世有限公司 2021-06-22 CN disclosed
EP-2805718-B1 HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME EA PHARMA CO LTD (JP) 2018-04-04 EP disclosed
WO-2018025872-A1 LIQUID CRYSTAL DISPLAY ELEMENT EQUIPPED WITH LIQUID CRYSTAL PANEL HAVING CURVED SURFACE AND LIQUID CRYSTAL ALIGNING AGENT FOR SAME 日産化学工業株式会社 2018-02-08 WO disclosed
US-9562043-B2 Heterocyclic amide derivative and pharmaceutical product containing same EA PHARMA CO., LTD. (JP) 2017-02-07 US disclosed
US-9562043-B2 Heterocyclic amide derivative and pharmaceutical product containing same EA PHARMA CO., LTD. (JP) 2017-02-07 US disclosed
EP-2805718-A1 HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME Ajinomoto Co., Inc. (JP) 2014-11-26 EP disclosed
US-20140329796-A1 HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME AJINOMOTO CO., INC. (JP) 2014-11-06 US disclosed
US-20140329796-A1 HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME AJINOMOTO CO., INC. (JP) 2014-11-06 US disclosed
US-20120053165-A1 Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators PFIZER INC. (US) 2012-03-01 US disclosed
US-20120053165-A1 Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators PFIZER INC. (US) 2012-03-01 US disclosed
WO-2012014898-A1 LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT 日産化学工業株式会社 (JP) 2012-02-02 WO disclosed
WO-2010100606-A1 NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS PFIZER INC. (US) 2010-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053165-A1 Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators BACE1, BACE2, PSEN1 LMNA 2176/4885MAPT 65/4885HTT 1177/4885
US-20140329796-A1 HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME TRPA1, TRPV1, TRPV2 LMNA 3279/4885MAPT 1109/4885HTT 444/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.