Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.66 |
| ▸ | CDK9 | P50750 | 2/20 | 0.66 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.55 |
| ▸ | MC5R | P33032 | 1/20 | 0.53 |
| ▸ | MC3R | P41968 | 1/20 | 0.53 |
| ▸ | MC1R | Q01726 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900043 | 0.87 | EIF2AK2 (0.75) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL4902818 | 0.84 | CCNT1 (0.71) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL20557614 | 0.83 | EIF2AK2 (0.61) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL30579418 | 0.80 | CCNT1 (0.67) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL3651615 | 0.79 | CDK2 (0.56) | CCNT1CCNA2CDK2CDK9MKNK1 | |
| SCHEMBL21903135 | 0.79 | EIF2AK2 (1.00) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL30586646 | 0.79 | EIF2AK2 (1.00) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL4895715 | 0.79 | NEK1 (0.47) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL4906716 | 0.79 | NEK1 (0.47) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL13039353 | 0.78 | CCNT1 (0.68) | CCNT1CCNA2CDK2CDK9EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | CCNT1 1479/4885CCNA2 490/4885CDK2 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.