Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 9/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | AKT2 | P31751 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | PRKX | P51817 | 2/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895715 | 1.00 | NEK1 (0.47) | NEK1AKT1EIF2AK2GSK3BCDK2 | |
| SCHEMBL4904597 | 0.88 | EIF2AK2 (0.49) | NEK1AKT1EIF2AK2CDK2FLT3 | |
| SCHEMBL4909073 | 0.82 | ECE1 (0.46) | NEK1AKT1EIF2AK2GSK3BCDK2 | |
| SCHEMBL4899730 | 0.81 | MEN1 (0.44) | NEK1GSK3BCDK2CDK1PRKACA | |
| SCHEMBL4903644 | 0.80 | DKK1 (0.40) | EIF2AK2GSK3BCDK2MAPK8CCNA2 | |
| SCHEMBL4907259 | 0.79 | CCNT1 (0.66) | EIF2AK2CDK2MKNK2CDK9CCNT1 | |
| SCHEMBL4906253 | 0.71 | DKK1 (0.36) | GSK3BCDK2CCNA2MAPK1DKK1 | |
| SCHEMBL4904630 | 0.71 | DKK1 (0.36) | GSK3BCDK2CCNA2MAPK1DKK1 | |
| SCHEMBL14161594 | 0.70 | HPGDS (0.44) | AKT1GSK3BCDK2PRKD3PRKCG | |
| SCHEMBL4900193 | 0.70 | DKK1 (0.36) | GSK3BCDK2CCNA2MAPK1DKK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | claimed |
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287452-A1 | HETEROARYL/ARYL PYRIMIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT3A, CTNNB1, WNT1 | NEK1 640/4885AKT1 194/4885EIF2AK2 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.