Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94097 | 0.87 | MEN1 (0.41) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| Hexane SCHEMBL28514659 | 0.74 | PTPN1 (0.40) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2996853 | 0.74 | MEN1 (0.43) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL29714477 | 0.72 | MEN1 (0.50) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL112133 | 0.72 | MEN1 (0.50) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL1248614 | 0.71 | TDO2 (0.31) | CA9 | |
| SCHEMBL30218501 | 0.70 | MEN1 (0.47) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL26128819 | 0.70 | MEN1 (0.47) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL3289725 | 0.69 | AHR (0.40) | APAF1TDP2ALDH1A1MAPTKMT2A | |
| SCHEMBL472878 | 0.68 | MEN1 (0.36) | APAF1TDP2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234348-A1 | 3-Oxoindazolesquaric Acid Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234348-A1 | 3-Oxoindazolesquaric Acid Derivatives | CHEK2, CHEK1, SGK2 | APAF1 3915/4885TDP2 1786/4885HDAC4 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.