Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | APAF1 | O14727 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GALK1 | P51570 | 2/20 | 0.35 |
| ▸ | S100A4 | P26447 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2765740 | 0.82 | MEN1 (0.36) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL94097 | 0.78 | MEN1 (0.41) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL7921203 | 0.70 | — | — | |
| SCHEMBL19603167 | 0.70 | NR1H2 (0.31) | — | |
| SCHEMBL2996853 | 0.70 | MEN1 (0.43) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL4217 | 0.69 | — | — | |
| SCHEMBL4907309 | 0.68 | APAF1 (0.37) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| Water SCHEMBL20742739 | 0.67 | MAPT (0.33) | MAPT | |
| SCHEMBL2294957 | 0.67 | MAPT (0.33) | MAPT | |
| Hexane SCHEMBL28514659 | 0.67 | PTPN1 (0.40) | MEN1KMT2AMAPTNPC1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10791743-B2 | EC formulations comprising organophosphate insecticides | SIPCAM OXON S.P.A. (IT) | 2020-10-06 | — | — | US | claimed |
| US-20180139964-A1 | EC FORMULATIONS COMPRISING ORGANOPHOSPHATE INSECTICIDES | SIPCAM SOCIETÁ ITALIANA PRODOTTI CHIMICI E PER L'AGRICOLTURA MILANO S.P.A. (IT) | 2018-05-24 | — | — | US | claimed |
| US-20180139963-A1 | EC FORMULATIONS COMPRISING ORGANOPHOSPHATE INSECTICIDES | SIPCAM OXON S.P.A. (IT) | 2018-05-24 | — | — | US | claimed |
| US-20180037606-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | APICORE US LLC (US) | 2018-02-08 | — | — | US | claimed |
| US-9822145-B2 | Methods of making carfilzomib and intermediates thereof | APICORE US LLC (US) | 2017-11-21 | — | — | US | claimed |
| US-20160340388-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | APICORE US LLC (US) | 2016-11-24 | — | — | US | claimed |
| WO-2016069479-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | APICORE US LLC (US) | 2016-05-06 | — | — | WO | claimed |
| US-20160115198-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2016-04-28 | — | — | US | claimed |
| US-7301006-B2 | Genetic engineering using azide modified amino acid; sulfating, phosphorylation, glycosylation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-11-27 | — | — | US | claimed |
| EP-0929567-B1 | SOLID-PHASE PEPTIDE SYNTHESIS | ZEALAND PHARMA AS (DK) | 2005-03-02 | — | — | EP | claimed |
| EP-0445862-B1 | N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2000-04-19 | — | — | EP | claimed |
| WO-1999061413-A1 | SUBSTITUTED 4-BIARYLBUTYRIC AND 5-BIARYLPENTANOIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1999-12-02 | — | — | WO | claimed |
| EP-0923529-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | Bayer Corporation (US) | 1999-06-23 | — | — | EP | claimed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | claimed |
| WO-1997043237-A1 | SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER CORPORATION (US) | 1997-11-20 | — | — | WO | claimed |
| US-5567823-A | Process for the preparation of an HIV protease inhibiting compound | ABBOTT LABORATORIES (US) | 1996-10-22 | — | — | US | claimed |
| US-5262418-A | Laxatives, gastrointestinal disorders | TANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-16 | — | — | US | claimed |
| US-5185335-A | Administer to mammals to stimulate gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-02-09 | — | — | US | claimed |
| EP-0445862-A2 | N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-09-11 | — | — | EP | claimed |
| US-4052373-A | O-AMINOESTER | FUJI PHOTO FILM CO., LTD. (JA) | 1977-10-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340388-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | MEN1 3663/4885KMT2A 2507/4885CDC25B 1310/4885 |
| US-10791743-B2 | EC formulations comprising organophosphate insecticides | C5, PHOSPHO1, ACHE | MEN1 1082/4885KMT2A 2188/4885CDC25B 275/4885 |
| US-20180037606-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | MEN1 3663/4885KMT2A 2507/4885CDC25B 1310/4885 |
| US-20160115198-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | MEN1 3663/4885KMT2A 2507/4885CDC25B 1310/4885 |
| US-20180139963-A1 | EC FORMULATIONS COMPRISING ORGANOPHOSPHATE INSECTICIDES | C5, PHOSPHO1, ACHE | MEN1 1082/4885KMT2A 2188/4885CDC25B 275/4885 |
| US-20180139964-A1 | EC FORMULATIONS COMPRISING ORGANOPHOSPHATE INSECTICIDES | ELOVL3, C9, C5 | MEN1 1006/4885KMT2A 2065/4885CDC25B 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.