Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30107706 | 0.92 | CYP3A4 (0.55) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL429872 | 0.92 | CYP3A4 (0.55) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL17386426 | 0.87 | CYP3A4 (0.53) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL4430256 | 0.86 | CYP3A4 (0.57) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL5135053 | 0.86 | SNCA (0.49) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL9278105 | 0.84 | SNCA (0.48) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL11046516 | 0.84 | PTPN11 (0.54) | SNCACYP3A4NPC1ALDH1A1HSD17B10 | |
| SCHEMBL18593579 | 0.84 | CA12 (0.53) | SNCACYP3A4NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9278114 | 0.84 | SNCA (0.48) | SNCACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL31182 | 0.83 | SNCA (0.59) | SNCACYP3A4MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345189-B2 | Process for the preparation of adapalene | DIPHARMA S.P.A. (IT) | 2008-03-18 | — | — | US | disclosed |
| EP-1707555-B1 | A process for the preparation of adapalene | LUNDBECK PHARMACEUTICALS ITALY (IT) | 2007-11-14 | — | — | EP | disclosed |
| US-20060229465-A1 | Process for the preparation of adapalene | LUNDBECK PHARMACEUTICALS ITALY S.P.A. (IT) | 2006-10-12 | — | — | US | disclosed |
| EP-1707555-A1 | A process for the preparation of adapalene | Dipharma S.p.A. (IT) | 2006-10-04 | — | — | EP | disclosed |
| US-5072021-A | Liquid crystals | MITSUI TOATSU CHEMICALS, INC. (JP) | 1991-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229465-A1 | Process for the preparation of adapalene | NR3C2, NR0B2, NR0B1 | SNCA 3874/4885CYP3A4 4009/4885MEN1 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.