Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SNCA | P37840 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13020459 | 0.89 | APP (0.45) | APPMAPTSNCACA12CA1 | |
| SCHEMBL14290169 | 0.86 | APP (0.66) | APPMAPTSNCAPPARG | |
| SCHEMBL12522849 | 0.84 | APP (0.49) | APPMAPTSNCA | |
| SCHEMBL5142551 | 0.81 | MEN1 (0.41) | APPMAPTSNCACA12CA1 | |
| SCHEMBL900444 | 0.79 | APP (0.37) | APPMAPTSNCACA12CA1 | |
| SCHEMBL4977529 | 0.78 | ENPP2 (0.40) | APPMAPTSNCACA12CA1 | |
| SCHEMBL17254447 | 0.77 | APP (0.69) | APPMAPTSNCAPPARG | |
| SCHEMBL20140463 | 0.77 | APP (0.59) | APPMAPTSNCA | |
| SCHEMBL17254450 | 0.76 | APP (0.78) | APPMAPTSNCAPPARG | |
| SCHEMBL951329 | 0.76 | APP (0.79) | APPMAPTSNCAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008522795-A | — | — | 2008-07-03 | — | — | JP | claimed |
| EP-1838431-A2 | MICROFLUIDIC DEVICES WITH CHEMICAL REACTION CIRCUITS | California Institute of Technology (US) | 2007-10-03 | — | — | EP | claimed |
| WO-2006071470-A2 | MICROFLUIDIC DEVICES WITH CHEMICAL REACTION CIRCUITS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2006-07-06 | — | — | WO | claimed |
| EP-3538161-A1 | METHODS FOR MULTI-DOSE SYNTHESIS OF [F-18]FDDNP FOR CLINICAL SETTINGS | The Regents of The University of California (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089491-A1 | METHODS FOR MULTI-DOSE SYNTHESIS OF [F-18]FDDNP FOR CLINICAL SETTINGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-17 | — | — | WO | disclosed |
| US-20140039074-A1 | METHOD FOR RAPID PREPARATION OF SUITABLE [18F]FLUORIDE FOR NUCLEOPHILIC [18F]FLUORINATION | PIRAMAL IMAGING SA (CH) | 2014-02-06 | — | — | US | disclosed |
| US-8206593-B2 | Adapted for on-chip solvent exchange; synthesis of radiopharmaceuticals such as FDG (fludeoxyglucose F18) for example | FLUIDIGM CORPORATION (US) | 2012-06-26 | — | — | US | disclosed |
| US-7847092-B2 | Method for preparation of F-18 containing organofluoro compounds in alcohol solvents | FUTURECHEM CO., LTD. (KR) | 2010-12-07 | — | — | US | disclosed |
| US-20100113763-A1 | METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS | FUTURECHEM CO., LTD. (KR) | 2010-05-06 | — | — | US | disclosed |
| US-20080281090-A1 | Microfluidic Chemical Reaction Circuits | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-11-13 | — | — | US | disclosed |
| US-7341709-B2 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles | REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 2008-03-11 | — | — | US | disclosed |
| US-20040258615-A1 | System and method for synthesis of molecular imaging probes including FDG | MOLECULAR TECHNOLOGIES, INC. | 2004-12-23 | — | — | US | disclosed |
| WO-2004093652-A2 | SYSTEM AND METHOD FOR SYNTHESIS OF MOLECULAR IMAGING PROBES INCLUDING FDG | MOLECULAR TECHNOLOGIES, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2004-04-15 | — | — | US | disclosed |
| US-6660530-B2 | Diagnosis of Alzheimer's disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-12-09 | — | — | US | disclosed |
| EP-1105163-A4 | METHODS FOR LABELING BETA-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | UNIV CALIFORNIA (US) | 2003-05-02 | — | — | EP | disclosed |
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-21 | — | — | US | disclosed |
| US-6274119-B1 | LABELING .BETA.-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES IN VIVO AND IN VITRO, COMPRISES CONTACTING RADIOLABELED AMINONAPTHALENE DERIVATIVE WITH MAMMALIAN TISSUE | THE REGENTS OF THE UNIV. OF CALIFORNIA | 2001-08-14 | — | — | US | disclosed |
| EP-1105163-A1 | METHODS FOR LABELING BETA-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010614-A1 | METHODS FOR LABELING β-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | OXSR1, MSR1, CBR1 | APP 11/4885MAPT 383/4885SNCA 98/4885 |
| US-20140039074-A1 | METHOD FOR RAPID PREPARATION OF SUITABLE [18F]FLUORIDE FOR NUCLEOPHILIC [18F]FLUORINATION | FASTKD5, NAF1, AFF4 | APP 2528/4885MAPT 3771/4885SNCA 1754/4885 |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | CBR1, CBR3, MSR1 | APP 5/4885MAPT 253/4885SNCA 93/4885 |
| US-20100113763-A1 | METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS | AFF1, AFF4, PFAS | APP 2771/4885MAPT 3217/4885SNCA 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.