Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 4/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798177 | 0.81 | KMT2A (0.65) | TDP1MAPTAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL4902552 | 0.80 | RAB9A (0.51) | MAPTAKR1C3MAPK1POLBKMT2A | |
| SCHEMBL11429763 | 0.77 | MAPT (0.59) | TDP1MAPTMAPK1POLBKMT2A | |
| SCHEMBL29565312 | 0.76 | MAPT (0.78) | TDP1MAPTAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL30776873 | 0.76 | MAPT (0.78) | TDP1MAPTAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL23675211 | 0.76 | MAPT (0.78) | TDP1MAPTAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL7020138 | 0.76 | AHR (0.51) | TDP1MAPTMAPK1POLBJAK2 | |
| SCHEMBL29141097 | 0.74 | MAPT (0.69) | TDP1MAPTAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL5416188 | 0.74 | GSK3B (0.65) | MAPTAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2365741 | 0.73 | MEN1 (0.62) | MAPTMAPK1KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | GLAXO GROUP LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| WO-2007067875-A2 | PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS | GLAXO GROUP LIMTED (GB) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293720-A1 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors | CCR2, CCR1, CCRL2 | TDP1 4723/4885MAPT 3959/4885AKR1C4 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.