Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37957 | 0.79 | PNP (0.53) | PNPMEN1ALDH1A1KMT2ABLM | |
| SCHEMBL7617798 | 0.79 | PNP (0.53) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL14079841 | 0.79 | PNP (0.66) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL2343355 | 0.78 | PNP (0.59) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL350396 | 0.76 | PNP (0.61) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7442898 | 0.76 | PNP (0.53) | PNPMEN1ALDH1A1KMT2AHIF1A | |
| SCHEMBL29980195 | 0.76 | PNP (0.53) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL1767745 | 0.75 | PNP (0.56) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL9960811 | 0.75 | PNP (0.71) | PNPMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL5935062 | 0.75 | PNP (0.70) | PNPMEN1ALDH1A1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139496-A1 | COMBINATION THERAPY FOR REDUCTION OF TOXICITY OF CHEMOTHERAPEUTIC AGENTS | CASCADE ESTATE LTD. (GB) | 2008-06-12 | — | — | US | disclosed |
| US-5849769-A | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection | MEDIVIR AB (SE) | 1998-12-15 | — | — | US | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5504093-A | ADMINISTERING A CARBOSTYRIL DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-02 | — | — | US | disclosed |