SCHEMBL4908448

SCHEMBL4908448

C=CC(=O)OCC(C#N)CCCCC

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 8/20 0.56
HPGD P15428 1/20 0.50
ALDH1A1 P00352 4/20 0.38
CYP3A4 P08684 2/20 0.38
ZDHHC20 Q5W0Z9 4/20 0.37
ZDHHC2 Q9UIJ5 3/20 0.37
THRB P10828 3/20 0.37
ZDHHC7 Q9NXF8 1/20 0.36
TP53 P04637 3/20 0.35
HIF1A Q16665 3/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPT P10636 1/20 0.35
HSD17B10 Q99714 1/20 0.34
THRA P10827 1/20 0.34
ATM Q13315 1/20 0.33
PLA2G2C Q5R387 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28470539 0.98 TSHR (0.55) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL4900024 0.95 TSHR (0.62) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL23838012 0.90 TSHR (0.51) TSHRHPGDALDH1A1CYP3A4THRB
SCHEMBL9831205 0.85 TSHR (0.60) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL1170959 0.83 TSHR (0.53) TSHRHPGDALDH1A1CYP3A4THRB
SCHEMBL1484077 0.80 TSHR (0.78) TSHRHPGDALDH1A1CYP3A4THRB
SCHEMBL10866454 0.80 TSHR (0.51) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL729461 0.79 TSHR (0.76) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL731354 0.79 TSHR (0.76) TSHRHPGDALDH1A1CYP3A4ZDHHC20
SCHEMBL991726 0.79 TSHR (0.61) TSHRHPGDALDH1A1CYP3A4THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5916741-A SUPPORT WITH A HYDROPHILIC LIGHT SENSITIVE LAYER EASTMAN KODAK COMPANY (US) 1999-06-29 US claimed
WO-2023094549-A1 FLEXIBLE PRESSURE-SENSITIVE ADHESIVES HAVING IMPROVED PROPERTIES WESTFÄLISCHE HOCHSCHULE GELSENKIRCHEN BOCHOLT RECKLINGHAUSEN (DE) 2023-06-01 WO disclosed
US-10889146-B2 Tire object provided with an elastomer layer made of a thermoplastic elastomer in the form of an (A-b-(a-methylstyrene-co-B))n-b-C block copolymer COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2021-01-12 US disclosed
US-10030131-B2 Pneumatic object provided with a gastight layer containing a thermoplastic elastomer and a thermoplastic COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-07-24 US disclosed
US-9914328-B2 Inflatable object provided with a gas-tight layer containing a thermoplastic elastomer and a hydrocarbon-based resin COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (CH) 2018-03-13 US disclosed
US-20180043734-A1 TIRE OBJECT PROVIDED WITH AN ELASTOMER LAYER MADE OF A THERMOPLASTIC ELASTOMER IN THE FORM OF AN (A-B-(A-METHYLSTYRENE-CO-B))N-B-C BLOCK COPOLYMER COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2018-02-15 US disclosed
US-20150290975-A1 PNEUMATIC TIRE WITH AN INNER LINER BONDED BY A FIBRE ASSEMBLY COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2015-10-15 US disclosed
US-20150079323-A1 PNEUMATIC OBJECT PROVIDED WITH A GASTIGHT LAYER BASED ON A THERMOPLASTIC ELASTOMER AND ON A LAMELLAR FILLER MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2015-03-19 US disclosed
US-20140343216-A1 TIRE PROVIDED WITH AN INNER LAYER COMPRISING A MIXTURE OF A DIENE ELASTOMER AND A THERMOPLASTIC ELASTOMER MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2014-11-20 US disclosed
US-20140343190-A1 TIRE PROVIDED WITH A TREAD MADE FROM A MIXTURE OF A DIENE ELASTOMER AND A THERMOPLASTIC ELASTOMER MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2014-11-20 US disclosed
US-20120149822-A1 PNEUMATIC OBJECT PROVIDED WITH A GASTIGHT LAYER MADE OF A THERMOPLASTIC ELASTOMER AND LAMELLAR FILLER MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2012-06-14 US disclosed
US-20120141696-A1 ELASTOMER COMPOSITION MADE FROM A THERMOPLASTIC COPOLYMER, INFLATABLE OBJECT PROVIDED WITH A GAS BARRIER MADE FROM SUCH A COMPOSITION SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2012-06-07 US disclosed
US-20080003288-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2008-01-03 US disclosed
US-7204997-B2 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2007-04-17 US disclosed
EP-1478403-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA, INC. (CA) 2004-11-24 EP disclosed
US-20030152623-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2003-08-14 US disclosed
WO-2003063909-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA INC. (US) 2003-08-07 WO disclosed
US-5916741-A SUPPORT WITH A HYDROPHILIC LIGHT SENSITIVE LAYER EASTMAN KODAK COMPANY (US) 1999-06-29 US disclosed
EP-0907666-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-14 EP disclosed
WO-1997049736-A2 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed