Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.46 |
| ▸ | CLK2 | P49760 | 4/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 4/20 | 0.46 |
| ▸ | CSNK1G3 | Q9Y6M4 | 4/20 | 0.46 |
| ▸ | AKT1 | P31749 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914854 | 0.86 | GSK3B (0.43) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4916029 | 0.86 | NTRK1 (0.45) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4906887 | 0.85 | MAPKAPK2 (0.54) | GSK3BROCK1PKN2AURKBROCK2 | |
| SCHEMBL4913538 | 0.84 | ROCK2 (0.42) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4905896 | 0.84 | ROCK2 (0.47) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4598469 | 0.82 | ROCK1 (0.41) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4909142 | 0.80 | CHEK2 (0.50) | GSK3BROCK1PKN2AURKBROCK2 | |
| SCHEMBL4914009 | 0.80 | EGFR (0.45) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL4598326 | 0.80 | MAPKAPK2 (0.41) | CA2CA1GSK3BROCK1PKN2 | |
| SCHEMBL1229917 | 0.79 | TTK (0.46) | GSK3BROCK1PKN2AURKBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | GLS, SGK1, PFKL | CA2 1707/4885CA1 4231/4885GSK3B 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.