Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 5/20 | 0.43 |
| ▸ | NEK4 | P51957 | 5/20 | 0.43 |
| ▸ | CLK2 | P49760 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | PRKX | P51817 | 3/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917069 | 0.82 | EGFR (0.50) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4919796 | 0.82 | GSK3B (0.48) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4906887 | 0.81 | MAPKAPK2 (0.54) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4916629 | 0.81 | EGFR (0.49) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4916045 | 0.80 | EGFR (0.57) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4909188 | 0.80 | CA2 (0.50) | MAPKAPK2GSK3BROCK1PKN2AURKB | |
| SCHEMBL4917914 | 0.80 | EGFR (0.46) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4599292 | 0.79 | HIF1A (0.48) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4913266 | 0.79 | ROCK2 (0.53) | EGFRMAPKAPK2GSK3BROCK1PKN2 | |
| SCHEMBL4909304 | 0.79 | EGFR (0.47) | EGFRMAPKAPK2GSK3BROCK1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | claimed |
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | GLS, SGK1, PFKL | EGFR 2751/4885MAPKAPK2 1309/4885GSK3B 977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.