Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917115 | 0.88 | MEN1 (0.50) | EGFRMAPK1MAPTKMT2AMEN1 | |
| SCHEMBL4911197 | 0.88 | EGFR (0.45) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4913538 | 0.87 | ROCK2 (0.42) | MAPK1GSK3BROCK1PRKG1CHEK2 | |
| SCHEMBL4917069 | 0.84 | EGFR (0.50) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4916629 | 0.83 | EGFR (0.49) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4919796 | 0.82 | GSK3B (0.48) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4906887 | 0.81 | MAPKAPK2 (0.54) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4909120 | 0.81 | EGFR (0.46) | EGFRMAPK1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL4916045 | 0.80 | EGFR (0.57) | EGFRMAPK1MAPTALDH1A1GSK3B | |
| SCHEMBL4917914 | 0.80 | EGFR (0.46) | EGFRMAPK1CYP1A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| US-20080262096-A1 | Squaric Acid Derivatives | MERCK PATENT GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1838662-A1 | SQUARIC ACID DERIVATIVES | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072354-A1 | SQUARIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262096-A1 | Squaric Acid Derivatives | GLS, SGK1, PFKL | EGFR 2751/4885MAPK1 1446/4885CYP1A2 2320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.