Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.67 |
| ▸ | DRD3 | P35462 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FPR3 | P25089 | 1/20 | 0.57 |
| ▸ | FPR2 | P25090 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14006003 | 0.84 | TSHR (0.70) | DRD2DRD3TSHRDRD4LMNA | |
| SCHEMBL14006126 | 0.83 | FPR2 (0.66) | DRD2DRD4MAPTSMN1; SMN2FPR3 | |
| SCHEMBL14005928 | 0.80 | DRD3 (0.63) | DRD2DRD3DRD4MAPTSMN1; SMN2 | |
| SCHEMBL7056439 | 0.79 | DRD2 (0.76) | DRD2DRD3TSHRDRD4 | |
| SCHEMBL10720828 | 0.79 | NPSR1 (0.68) | DRD2DRD3DRD4LMNAALDH1A1 | |
| SCHEMBL14005944 | 0.78 | DRD2 (0.51) | DRD2DRD3DRD4LMNAALDH1A1 | |
| SCHEMBL14006136 | 0.78 | DRD3 (0.58) | DRD2DRD3DRD4MAPTSMN1; SMN2 | |
| SCHEMBL7055571 | 0.77 | DRD2 (0.66) | DRD2DRD3TSHRDRD4 | |
| SCHEMBL14006045 | 0.77 | DRD3 (0.59) | DRD2DRD3DRD4MAPTSMN1; SMN2 | |
| SCHEMBL7132544 | 0.77 | DRD2 (0.74) | DRD2DRD3DRD4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275028-A1 | Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof | SIENA BIOTECH S.P.A. (IT) | 2008-11-06 | — | — | US | disclosed |
| CN-101018774-A | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof | SIENA BIOTECH SPA (IT) | 2007-08-15 | — | — | CN | disclosed |
| EP-1778658-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006008133-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275028-A1 | Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof | CHRNA7, CHRNA5, CHRNA1 | DRD2 582/4885DRD3 597/4885TSHR 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.