Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9651254 | 0.90 | MAPT (0.50) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5174637 | 0.90 | MMP14 (0.51) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5172965 | 0.90 | MMP14 (0.51) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL9651259 | 0.90 | MAPT (0.50) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7465193 | 0.90 | MAPT (0.51) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5382472 | 0.85 | GAA (0.49) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL27927482 | 0.81 | MAPT (0.68) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL5692166 | 0.81 | MAPT (0.62) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL17525043 | 0.81 | MAPT (0.49) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL168393 | 0.81 | ALDH1A1 (0.54) | MAPTALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106631874-B | Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-acetyl group -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-05-10 | — | — | CN | claimed |
| CN-106631857-B | Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-05-10 | — | — | CN | claimed |
| CN-106631876-B | (2- the chloroethyl)-N '-myristoyl of nitrogen mustard derivatives N, N- bis- base-Isosorbide-5-Nitrae-phenylenediamine and preparation method thereof | 长安大学 | 2019-05-03 | — | — | CN | claimed |
| CN-106631875-B | Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-hexadecanoyl group -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-05-03 | — | — | CN | claimed |
| CN-106631856-B | Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-benzoyl -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-03-19 | — | — | CN | claimed |
| CN-106631857-A | Aryl nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-propionyl-1,4-phenylenediamine and preparation method thereof | 长安大学 | 2017-05-10 | — | — | CN | claimed |
| CN-106631876-A | Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-myristoyl-1,4-phenylenediamine and preparation method thereof | 长安大学 | 2017-05-10 | — | — | CN | claimed |
| CN-106631856-A | Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine and preparation method thereof | 长安大学 | 2017-05-10 | — | — | CN | claimed |
| CN-106631874-A | Arylamine nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-acetyl-1,4-phenylenediamine and preparation method thereof | 长安大学 | 2017-05-10 | — | — | CN | claimed |
| CN-106631875-A | Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof | 长安大学 | 2017-05-10 | — | — | CN | claimed |
| CN-114516849-B | Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine | 江苏恒盛药业有限公司 | 2025-04-29 | — | — | CN | disclosed |
| CN-114516849-A | Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine | 江苏恒盛药业有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-106631857-B | Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-106631874-B | Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-acetyl group -1,4- phenylenediamine and preparation method thereof | 长安大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-106631876-B | (2- the chloroethyl)-N '-myristoyl of nitrogen mustard derivatives N, N- bis- base-Isosorbide-5-Nitrae-phenylenediamine and preparation method thereof | 长安大学 | 2019-05-03 | — | — | CN | disclosed |
| US-5587161-A | TWO COMPONENT SYSTEM INCLUDING ANTIBODY OR ANTIGEN BINDING FRAGMENT CONJUGATED TO CARBOXYPEPTIDASE G ENZYME, COMPOUND CONVERTIBLE TO CYTOTOXIC DRUG UNDER INFLUENCE OF ENZYME | ZENECA LIMITED (GB) | 1996-12-24 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |
| EP-0651740-A1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LIMITED (GB) | 1995-05-10 | — | — | EP | disclosed |
| US-5405990-A | For use in antibody directed enzyme prodrug therapy; cytotoxic parent nitrogen mustard; antitumor agents | ZENECA LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |
| WO-1994002450-A1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |