⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300395 | 0.96 | — | — | |
| SCHEMBL2463396 | 0.96 | ADH1B (0.39) | — | |
| SCHEMBL29431604 | 0.92 | ADH1B (0.43) | — | |
| SCHEMBL491426 | 0.91 | NOS1 (0.39) | — | |
| SCHEMBL23070439 | 0.87 | CHRM5 (0.43) | — | |
| SCHEMBL2708909 | 0.87 | — | — | |
| SCHEMBL1930290 | 0.87 | CHRM5 (0.43) | — | |
| SCHEMBL187659 | 0.87 | CHRM5 (0.43) | — | |
| SCHEMBL3224864 | 0.87 | CHRM5 (0.43) | — | |
| SCHEMBL1524658 | 0.87 | CHRM5 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220024926-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-01-27 | — | — | US | claimed |
| CN-111362838-A | Urea group-containing diimine palladium catalyst, ligand thereof and application thereof in olefin polymerization | 中国科学技术大学 | 2020-07-03 | — | — | CN | claimed |
| WO-2020118139-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-06-11 | — | — | WO | claimed |
| EP-1713822-B1 | HCV NS-3 SERINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-03-17 | — | — | EP | claimed |
| US-20080171662-A1 | Aminocarbonyl-Substituted Thiensulfonylamino(Thio)Carbonyl-Triazolin(Ethi)Ones, Processes For Their Preparation And Their Use | BAYER CROPSCIENCE AG (DE) | 2008-07-17 | — | — | US | claimed |
| US-20070161574-A1 | Hcv ns-3 serine protease inhibitors | MEDIVIR AB (SE) | 2007-07-12 | — | — | US | claimed |
| EP-1776012-A1 | AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF | Bayer CropScience Aktiengesellschaft (DE) | 2007-04-25 | — | — | EP | claimed |
| EP-1713822-A2 | HCV NS-3 SERINE PROTEASE INHIBITORS | Medivir Aktiebolag (SE) | 2006-10-25 | — | — | EP | claimed |
| WO-2006012981-A1 | AMINOCARBONYL-SUBSTITUTED THIENYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2006-02-09 | — | — | WO | claimed |
| WO-2006012983-A1 | AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF | BAYER CROPSCIENCE AG (DE) | 2006-02-09 | — | — | WO | claimed |
| EP-1623987-A1 | Fused pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and pyrido[3',2':4,5]furo[3,2-d]pyrimidines | Curacyte Discovery GmbH (DE) | 2006-02-08 | — | — | EP | claimed |
| WO-2006010568-A2 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | claimed |
| EP-1619197-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | claimed |
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | claimed |
| WO-2005073216-A2 | HCV NS-3 SERINE PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2005-08-11 | — | — | WO | claimed |
| EP-1090005-B1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-08-20 | — | — | EP | claimed |
| US-6509338-B1 | Psychiatric disorders and neurological diseases including affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | claimed |
| EP-1090005-A1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-11 | — | — | EP | claimed |
| WO-1999067247-A1 | PYRAZOLO[1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-29 | — | — | WO | claimed |
| WO-2023111181-A1 | SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2023-06-22 | — | — | WO | disclosed |
| US-20220024926-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-01-27 | — | — | US | disclosed |
| CN-111362838-B | Urea group-containing diimine palladium catalyst, ligand thereof and application thereof in olefin polymerization | 中国科学技术大学 | 2021-05-07 | — | — | CN | disclosed |
| CN-111362838-A | Urea group-containing diimine palladium catalyst, ligand thereof and application thereof in olefin polymerization | 中国科学技术大学 | 2020-07-03 | — | — | CN | disclosed |
| WO-2020118139-A1 | A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-06-11 | — | — | WO | disclosed |
| US-20140221472-A1 | USE OF MYRICETIN OR DERIVATIVES THEREOF AS A CATHEPSIN K INHIBITOR | JILINSHENG JINZIYUAN BIOTECHNOLOGY LTD (CN) | 2014-08-07 | — | — | US | disclosed |
| EP-2762137-A1 | Use of myricetin or derivatives thereof as a cathepsin k inhibitor | Jilinsheng Jinziyuan Biotechnology Ltd. (CN) | 2014-08-06 | — | — | EP | disclosed |
| US-20120094987-A1 | SUBSTITUTED PYRIDO [3', 2': 4, 5] THIENO [3, 2-D] PYRIMIDINES AND PYRIDO [3', 2': 4, 5] FURO [3, 2-D] PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF-alpha | CURACYTE DISCOVERY GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| US-8106194-B2 | Pyrrolopyrimidine and pyrrolotriazine derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-8058285-B2 | Phosphodiesterase-4 (PDE-4) inhibitors; for treating bronchial asthma, COPD, rheumatoid arthritis (RA), osteoarthritis, cystic fibrosis, Guillain-Barresyndrome, Crohn's disease, ulcerative colitis, psoriasis, atopic dermatitis, allergic eczemas | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| US-20110137031-A1 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-06-09 | — | — | US | disclosed |
| EP-1773840-B1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | MEDICINES CO LEIPZIG GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |
| US-20080171662-A1 | Aminocarbonyl-Substituted Thiensulfonylamino(Thio)Carbonyl-Triazolin(Ethi)Ones, Processes For Their Preparation And Their Use | BAYER CROPSCIENCE AG (DE) | 2008-07-17 | — | — | US | disclosed |
| US-20080160028-A1 | SUBSTITUTED PYRIDO [3', 2': 4, 5] THIENO [3, 2-D] PYRIMIDINES AND PYRIDO [3', 2': 4, 5] FURO [3, 2-D] PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF-ALPHA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2008-07-03 | — | — | US | disclosed |
| US-20070270588-A1 | Pyrrolopyrimidine Derivatives | TAISHO PHARMACEUTICAL CO., LTD. | 2007-11-22 | — | — | US | disclosed |
| EP-1776012-A1 | AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF | Bayer CropScience Aktiengesellschaft (DE) | 2007-04-25 | — | — | EP | disclosed |
| EP-1773840-A1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | Curacyte Discovery GmbH (DE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1725562-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-11-29 | — | — | EP | disclosed |
| EP-1706410-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-10-04 | — | — | EP | disclosed |
| US-7098217-B2 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-29 | — | — | US | disclosed |
| US-7045529-B2 | Imidazopyrimidinyl and imidazopyri dinyl derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-16 | — | — | US | disclosed |
| WO-2006012981-A1 | AMINOCARBONYL-SUBSTITUTED THIENYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2006-02-09 | — | — | WO | disclosed |
| WO-2006012983-A1 | AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF | BAYER CROPSCIENCE AG (DE) | 2006-02-09 | — | — | WO | disclosed |
| EP-1623987-A1 | Fused pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and pyrido[3',2':4,5]furo[3,2-d]pyrimidines | Curacyte Discovery GmbH (DE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2006010568-A2 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006010567-A1 | SUBSTITUTED PYRIDO[3', 2': 4, 5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3', 2': 4, 5]FURO[3, 2, D]PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF$G(A) | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |
| EP-1619197-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |
| WO-2005085253-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-09-15 | — | — | WO | disclosed |
| WO-2005066142-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-21 | — | — | WO | disclosed |
| US-6894045-B2 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-20050026937-A1 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-02-03 | — | — | US | disclosed |
| EP-1090005-B1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6509338-B1 | Psychiatric disorders and neurological diseases including affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |
| EP-1244666-A1 | IMIDAZOPYRIMIDINYL AND IMIDAZOPYRIDINYL DERIVATIVES | Bristol-Myers Squibb Pharma Company (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044248-A1 | IMIDAZOPYRIMIDINYL AND IMIDAZOPYRIDINYL DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |
| US-5583015-A | CULTURING MUTANT STRAIN OF STREPTOMYCES AVERMITILIS LACKING BRANCHED CHAIN AMINO ACID TRANSAMINASE AND/OR 2-OXO ACID DEHYDROGENASE ACTIVITY UNDER AEROBIC CONDITIONS IN AQUEOUS NUTRIENT MEDIUM CONTAINING SPECIFIED ACID OR PRECURSOR | PFIZER INC. (US) | 1996-12-10 | — | — | US | disclosed |
| US-4822635-A | Sweetening with L-aminodicarboxylic acid esters | GENERAL FOODS CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |
| US-4788073-A | Sweetening with L-aminodicarboxylic acid alkenes | GENERAL FOODS CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
| US-4788332-A | ARTIFICAL SWEETENER | GENERAL FOODS CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
| US-4781927-A | Sweetening with l-aminodicarboxylic acid esters | GENERAL FOODS CORPORATION (US) | 1988-11-01 | — | — | US | disclosed |
| US-4766246-A | L-aminodicarboxylic acid esters | GENERAL FOODS CORPORATION (US) | 1988-08-23 | — | — | US | disclosed |
| US-4760175-A | L-aminodicarboxylic acid alkenes | GENERAL FOODS CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| US-4701552-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-10-20 | — | — | US | disclosed |
| US-4698231-A | Sweetening with L-aminodicarboxylic acid amides | GENERAL FOOD CORPORATION (US) | 1987-10-06 | — | — | US | disclosed |
| US-4678675-A | Sweetening with L-aminodicarboxylic acid alkenes | GENERAL FOODS CORPORATION (US) | 1987-07-07 | — | — | US | disclosed |
| US-4678674-A | Sweetening with L-aminodicarboxylic acid amides | GENERAL FOODS CORPORATION (US) | 1987-07-07 | — | — | US | disclosed |
| US-4676989-A | Sweetening with cycloalkyl ethers and thioethers of dipeptides | GENERAL FOODS CORPORATION (US) | 1987-06-30 | — | — | US | disclosed |
| US-4654219-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |
| US-4652676-A | L-aminodicarboxylic acid alkenes | GENERAL FOODS CORPORATION (US) | 1987-03-24 | — | — | US | disclosed |
| US-4638071-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-01-20 | — | — | US | disclosed |
| US-4636396-A | Foodstuff with L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |
| EP-0203540-A1 | L-Aminodicarboxylic acid amides of substituted amines and a composition containing the same | GENERAL FOODS CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |
| EP-0201844-A1 | L-Aminodicarboxylic acid alkenes and an edible composition containing same | GENERAL FOODS CORPORATION (US) | 1986-11-20 | — | — | EP | disclosed |
| EP-0201078-A1 | L-Aminodicarboxylic acid aminoalkenoic acid ester amides and the use thereof | GENERAL FOODS CORPORATION (US) | 1986-11-12 | — | — | EP | disclosed |
| EP-0201077-A1 | L-Aminodicarboxylic acid alkanes and an edible composition containing same | GENERAL FOODS CORPORATION (US) | 1986-11-12 | — | — | EP | disclosed |
| US-4622232-A | L-aminodicarboxylic acid alkanes | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| US-4622417-A | DIETETICS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| US-4622418-A | LOW CALORIE SWEETENERS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0199258-A2 | L-Aminodicarboxylic acid amides and an edible composition containing same | GENERAL FOODS CORPORATION (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4619782-A | L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1986-10-28 | — | — | US | disclosed |
| US-4619834-A | Sweetening with L-aminodicarboxylic acid aminoalkenoic acid ester amides | GENERAL FOODS CORPORATION (US) | 1986-10-28 | — | — | US | disclosed |
| US-4603012-A | L-aminodicarboxylic acid alkanes | GENERAL FOODS CORPORATION (US) | 1986-07-29 | — | — | US | disclosed |
| US-4572799-A | L-Aminodicarboxylic acid amides | GENERAL FOODS CORPORATION (US) | 1986-02-25 | — | — | US | disclosed |
| US-4571308-A | L-Aminodicarboxylic acid aminoalkenoic acid ester amides | GENERAL FOODS CORPORATION (US) | 1986-02-18 | — | — | US | disclosed |
| US-4571308-A | L-Aminodicarboxylic acid aminoalkenoic acid ester amides | GENERAL FOODS CORPORATION (US) | 1986-02-18 | — | — | US | disclosed |