Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649031 | 0.96 | ADRB3 (0.42) | ADRB3HPGDNR1I2ADRB2PTPN5 | |
| SCHEMBL4916127 | 0.96 | ADRB3 (0.42) | ADRB3HPGDNR1I2ADRB2PTPN5 | |
| SCHEMBL4649132 | 0.96 | ADRB3 (0.42) | ADRB3HPGDNR1I2ADRB2PTPN5 | |
| Trifluoroacetic Acid SCHEMBL4913411 | 0.92 | ADRB3 (0.41) | ADRB3HPGDNR1I2KEAP1NFE2L2 | |
| Trifluoroacetic Acid SCHEMBL4907969 | 0.91 | ADRB3 (0.41) | ADRB3HPGDNR1I2KEAP1NFE2L2 | |
| Trifluoroacetic Acid SCHEMBL4916366 | 0.91 | ADRB3 (0.41) | ADRB3HPGDNR1I2KEAP1NFE2L2 | |
| Trifluoroacetic Acid SCHEMBL4908055 | 0.90 | ADRB3 (0.46) | ADRB3HPGDNR1I2ADRB2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4642328 | 0.90 | ADRB3 (0.41) | ADRB3HPGDNR1I2ADRB2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4605859 | 0.89 | ADRB3 (0.42) | ADRB3HPGDNR1I2ALDH1A1ADRA1A | |
| Trifluoroacetic Acid SCHEMBL4644337 | 0.89 | ADRB3 (0.42) | ADRB3HPGDNR1I2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103138-A1 | Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-01 | — | — | US | disclosed |
| US-20070112033-A1 | N-(3-{2-[3-(6-amino-benzimidazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide; beta(3)-Adrenoceptor agonists; antidiabetic, obesity, insulin resistance | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103138-A1 | Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions | ADRB1, ADRB3, ADRB2 | ADRB3 2/4885HPGD 1119/4885NR1I2 307/4885 |
| US-20070112033-A1 | N-(3-{2-[3-(6-amino-benzimidazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide; beta(3)-Adrenoceptor agonists; antidiabetic, obesity, insulin resistance | ADRB3, ADRB1, ADRA1B | ADRB3 1/4885HPGD 2957/4885NR1I2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.