SCHEMBL4915215

SCHEMBL4915215

N#Cc1cccc(-c2nc(C(=O)N(O)C3CCCCC3)c(CO)n2-c2ccc(OS(=O)(=O)CCC(F)(F)F)cc2)c1

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 15/20 0.41
CXCR3 P49682 1/20 0.33
MCHR1 Q99705 1/20 0.32
MCOLN3 Q8TDD5 1/20 0.32
CPT2 P23786 2/20 0.32
CPT1A P50416 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4902404 0.92 CNR1 (0.47) CNR1MCOLN3
SCHEMBL4923174 0.91 CNR1 (0.42) CNR1CXCR3
SCHEMBL4915199 0.84 CNR1 (0.58) CNR1
SCHEMBL4913958 0.83 CNR1 (0.51) CNR1
SCHEMBL4922305 0.82 CNR1 (0.36) CNR1CXCR3
SCHEMBL4917463 0.81 CNR1 (0.61) CNR1
SCHEMBL4796011 0.79 CNR1 (0.36) CNR1MCOLN3
SCHEMBL4922312 0.78 CNR1 (0.41) CNR1
SCHEMBL4637589 0.77 CNR1 (0.69) CNR1
SCHEMBL4925530 0.76 CNR1 (0.51) CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080319019-A1 Therapeutic Agents ASTRAZENECA AB (SE) 2008-12-25 US claimed
US-20080319019-A1 Therapeutic Agents ASTRAZENECA AB (SE) 2008-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080319019-A1 Therapeutic Agents SDHA, GPR119, ABAT CNR1 393/4885CXCR3 4701/4885MCHR1 926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.