SCHEMBL4902404

SCHEMBL4902404

Cc1c(C(=O)N(O)C2CCCCC2)nc(-c2cccc(C#N)c2)n1-c1ccc(OS(=O)(=O)CCC(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 18/20 0.47
KDM1A O60341 1/20 0.36
MCOLN3 Q8TDD5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4915215 0.92 CNR1 (0.41) CNR1MCOLN3
SCHEMBL4637589 0.84 CNR1 (0.69) CNR1KDM1A
SCHEMBL4923174 0.83 CNR1 (0.42) CNR1
SCHEMBL4638248 0.82 CNR1 (0.59) CNR1
SCHEMBL4796011 0.81 CNR1 (0.36) CNR1MCOLN3
SCHEMBL4896075 0.77 CNR1 (0.48) CNR1
SCHEMBL4915199 0.77 CNR1 (0.58) CNR1
SCHEMBL4897033 0.76 CNR1 (0.58) CNR1KDM1A
SCHEMBL4891089 0.75 CNR1 (0.37) CNR1
SCHEMBL4897349 0.75 CNR1 (0.68) CNR1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080306115-A1 Midazole-4-Carboxamide Derivatives For Use As Cb1 Modulators ASTRAZENECA AB (SE) 2008-12-11 US claimed
US-20080306115-A1 Midazole-4-Carboxamide Derivatives For Use As Cb1 Modulators ASTRAZENECA AB (SE) 2008-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080306115-A1 Midazole-4-Carboxamide Derivatives For Use As Cb1 Modulators CNR2, CNR1, FAAH CNR1 2/4885KDM1A 864/4885MCOLN3 618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.