Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LIG1 | P18858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564034 | 0.86 | CTSD (0.70) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL6329484 | 0.84 | CTSD (0.72) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL16193193 | 0.81 | CTSD (0.68) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL7748621 | 0.81 | CTSD (0.68) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL30349208 | 0.81 | CTSD (1.00) | CTSDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL295407 | 0.81 | CTSD (1.00) | CTSDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL11326953 | 0.79 | CTSD (0.66) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL17479848 | 0.79 | CTSD (0.66) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL239328 | 0.79 | CTSD (0.63) | CTSDMEN1KMT2ACA1CA2 | |
| SCHEMBL30547074 | 0.79 | CTSD (0.63) | CTSDMEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000053577-A9 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | US GOV HEALTH & HUMAN SERV (US) | 2001-09-20 | — | — | WO | claimed |
| WO-2000053577-A1 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2000-09-14 | — | — | WO | claimed |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
| EP-1187837-B1 | THIAZEPINE INHIBITORS OF HIV-1 INTEGRASE | US HEALTH (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1742642-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2006-06-01 | — | — | US | disclosed |
| US-7015212-B1 | Thiazepine inhibitors of HIV-1 integrase | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-03-21 | — | — | US | disclosed |
| WO-2005117904-A2 | PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| EP-1187837-A1 | THIAZEPINE INHIBITORS OF HIV-1 INTEGRASE | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000053577-A9 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | US GOV HEALTH & HUMAN SERV (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000053577-A9 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | US GOV HEALTH & HUMAN SERV (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000068235-A1 | THIAZEPINE INHIBITORS OF HIV-1 INTEGRASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2000-11-16 | — | — | WO | disclosed |
| WO-2000053577-A1 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2000-09-14 | — | — | WO | disclosed |
| WO-2000053577-A1 | HYDRAZIDE INHIBITORS OF HIV-1 INTEGRASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH (US) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116356-A1 | Phosphonate analogs of HIV integrase inhibitor compounds | TYMP, PNP, PIKFYVE | CTSD 3468/4885MEN1 4347/4885KMT2A 1777/4885 |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | CTSD 3468/4885MEN1 4347/4885KMT2A 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.