Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661488 | 0.89 | GRM2 (0.41) | GABRG2GABRB3GABRA2GRM5 | |
| SCHEMBL4920872 | 0.88 | CRHR1 (0.47) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL2661947 | 0.87 | CRHR1 (0.46) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL2661938 | 0.87 | GABRG2 (0.38) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL2661576 | 0.87 | CRHR1 (0.41) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL4919724 | 0.86 | CRHR1 (0.41) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL2656734 | 0.85 | BACE1 (0.38) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL2669415 | 0.85 | GABRG2 (0.43) | CRHR1GABRG2GABRB3GABRA2GRM5 | |
| SCHEMBL2661222 | 0.85 | CRHR1 (0.42) | CRHR1GABRG2GABRB3GABRA2GABRA1 | |
| SCHEMBL4925336 | 0.85 | HRH4 (0.40) | BACE1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | claimed |
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | CRHR1 60/4885GABRG2 592/4885GABRB3 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.