Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661049 | 1.00 | HRH4 (0.37) | HRH4PARP1PARP2ADORA1 | |
| SCHEMBL2660878 | 0.89 | PARP1 (0.38) | HRH4PARP1PARP2ADORA1 | |
| SCHEMBL4921710 | 0.86 | PARP1 (0.40) | HRH4PARP1PARP2ADORA1 | |
| SCHEMBL2660900 | 0.86 | PARP1 (0.38) | HRH4PARP1PARP2ADORA1 | |
| SCHEMBL2655216 | 0.80 | HRH4 (0.42) | HRH4PARP1ADORA1 | |
| SCHEMBL2656853 | 0.79 | HRH4 (0.38) | HRH4ADORA1 | |
| SCHEMBL2669418 | 0.78 | PIK3CA (0.39) | HRH4 | |
| SCHEMBL4925266 | 0.78 | GABRG2 (0.43) | — | |
| SCHEMBL13991075 | 0.78 | PIK3CA (0.39) | HRH4 | |
| SCHEMBL4915461 | 0.78 | PIK3CA (0.39) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318943-A1 | Compounds and Uses Thereof - 848 | COMT, BACE1, BDNF | HRH4 167/4885PARP1 1350/4885PARP2 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.