Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 9/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 9/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 9/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 9/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 9/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034000 | 0.83 | GRIN2D (0.55) | MAPTALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL27882424 | 0.80 | EED (0.50) | MAPTLMNAALDH1A1GRIN2DGRIN3B | |
| SCHEMBL19381534 | 0.79 | GRIN2D (0.54) | MAPTMAPK1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4911205 | 0.76 | ALDH1A1 (0.65) | MAPTLMNAALDH1A1MAPK1TDP1 | |
| SCHEMBL17265648 | 0.76 | ALDH1A1 (0.77) | MAPTLMNAALDH1A1MAPK1GFER | |
| SCHEMBL3425880 | 0.76 | ALDH1A1 (0.46) | MAPTLMNAALDH1A1MAPK1GRIN2D | |
| SCHEMBL5622578 | 0.74 | ALDH1A1 (0.59) | MAPTLMNAALDH1A1MAPK1GFER | |
| SCHEMBL23043587 | 0.74 | GRIN2D (0.59) | MAPTLMNAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29375196 | 0.74 | EED (0.64) | MAPTALDH1A1GFERGRIN2DGRIN3B | |
| SCHEMBL29979114 | 0.74 | GRIN2D (0.59) | MAPTLMNAGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214808-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LIMITED (GB) | 2012-08-23 | — | — | US | disclosed |
| US-20120214808-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LIMITED (GB) | 2012-08-23 | — | — | US | disclosed |
| US-20120214808-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LIMITED (GB) | 2012-08-23 | — | — | US | disclosed |
| US-20080261952-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LTD. (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080261952-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LTD. (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080261952-A1 | Aryl Urea Derivatives for Treating Obesity | PROSIDION LTD. (GB) | 2008-10-23 | — | — | US | disclosed |
| EP-1786422-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | Prosidion Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006018662-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | PROSIDION LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |
| WO-2003106454-A1 | 1H-ISOQUINOLINE-OXAZOLIDINONE DERIVATIES AND THEIR USE AS ANTIBACTERIAL AGENTS | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261952-A1 | Aryl Urea Derivatives for Treating Obesity | CNR1, GPR119, UTS2R | MAPT 4151/4885LMNA 4374/4885ALDH1A1 274/4885 |
| US-20120214808-A1 | Aryl Urea Derivatives for Treating Obesity | CNR1, GPR119, UTS2R | MAPT 4151/4885LMNA 4374/4885ALDH1A1 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.